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Four structural limitations define how the evidence must be interpreted before any application to humans is considered

Research Overview Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, producing 1-methylnicotinamide and S-adenosyl-L-homocysteine [1]

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To our knowledge, there have only been three published studies