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This multifaceted disruption impairs the BBBs normal homeostatic roles and directly influences neural activity

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This is further exemplified by its HmuY protein, which can efficiently sequester heme from Bacteroides fragilis proteins like BfrA, potentially disrupting microbial mutualism in the gut and exacerbating dysbiosis ( P.g exhibits a pronounced tropism for the intestinal mucosa, demonstrating a higher adhesive capacity to intestinal epithelial cells compared to other oral bacteria like Prevotella intermedia , an action primarily mediated by its gingipain proteases (Motosugi et al., 2025)

Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy