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Similarly, arginine plays a vital role as a precursor to nitric oxide (NO) [31], a molecule that helps regulate blood flow, modulate immune responses, and support detoxification processes [32]

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doi: 10.1186/s12967-020-02267-2 43 LeeMSMoonEJLeeSWKimMSKimKWKimYJet al

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This raises an intriguing question of whether alternative sources of energy, such as ketone bodies by-passing the glycolytic pathway, might lead to increases in energy, and indeed some studies showed a reduction in fatigue in ME/CFS on a ketone diet [80]

63 The expression of MTHFD2 is closely related to the response of the folate antagonist methotrexate (MTX) and the thymidylate synthase inhibitor pemetrexed