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A trial looking at cancer prevention from consuming flavonoid-rich vegetables, including luteolin content, found no difference in cancer risk among women who consumed the most flavonoids compared to the least.[ref] Luteolin for skin health and sunburns: A clinical trial found that a nanoparticle formula containing a luteolin-rich plant extract decreased UVB-induced erythema (e.g., sunburns)

Similarly, demethylated HIV-1 RNA has been shown to upregulate Type I IFN in dendritic cells via MDA5 activation [316]

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