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Increased cAMP levels might activate protein kinase A (PKA), which may phosphorylate various proteins, including those forming voltage-dependent calcium channels on the cell membrane

As shown in Figure 2, we found that following abdominal surgery and intestinal manipulation, there was a marked inhibition of the smooth muscle contractile responses to cholinergic stimulation with ACh at 100 M compared to that observed in isolated gastric fundic smooth muscle preparations from nonsurgery control rats

In contrast, another study demonstrated that Cys-93 in the -subunit of Hb (where this nitrosothiol is formed) is not essential for RBC-dependent hypoxic vasodilation (83), thus implicating other NO metabolites or pathways

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MedGenMed (2006) 8(4):60

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