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Nanomaterials (2024) 14(13):10855

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Patients with kidney disease or heart disease may not be able to process high vitamin concentrations at once

A particular although not exclusive importance for apoptotic cell death with bilirubin toxicity was suggested by the observation that inhibition of the proapoptotic enzyme p38 MAP kinase by minocycline prevented cerebellar neuronal cell death with bilirubin exposure

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Because the body naturally utilizes what it needs and safely filters the rest, toxicity is exceptionally rare in individuals with normal kidney function