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Therefore, although very potent in terms of directly tackling brain iron overload, a non-invasive but direct method is necessary for CNS delivery

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If the PCAC issues favorable recommendations and the FDA subsequently reclassifies any of these peptides into Category 1, the availability of pharmaceutical-grade API will likely become the principal bottleneck governing how quickly compounding pharmacies can bring compliant products to market

Specifically, TAPP (APPSwe-Tau) mice exhibit an association of aggressive behavior with phosphorylated tau localized to lateral parabrachial (LPB) neurons (Warfield et al., 2023)

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