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In the duodenum, pancreatic enzymes cleave B12 from R-proteins, allowing binding to intrinsic factor produced by gastric parietal cells

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Ann Thorac Surg 73(2):420-5

Since glutamate is one of the brains major excitatory neurotransmitters, this pathway has drawn interest in conditions such as obsessive-compulsive disorder (OCD), depression, bipolar disorder, and substance use disorders.11 29 The evidence is still uneven