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30-50% of patients experience CIPN with low dose regimens but at higher doses as many as 90% of patients experience neuropathy making it an important dose limiting toxicity (1)

A consistent estimation of the causal effect can be obtained using the weighted median method if the weighted median of the SNP-specific estimates reaches 50% ( p -values below 0.0012 (0.05/42) as indicating strong evidence of associations in the MR analysis between the six endogenous antioxidants and six cancers