This study aimed to compare the effectiveness and safety of LY3298176 with a placebo and with dulaglutide, a drug that stimulates only the GLP-1 receptor
There is no authorised evidence that one form is superior
Anyone can be affected, but some groups are more at risk: Vegetarians and vegans, since B12 mainly comes from animal products Older adults, as absorption gets harder with age People with digestive issues like Crohns or coeliac disease Those taking certain medications, such as long-term metformin or stomach acid reducers People with pernicious anaemia, an autoimmune condition that stops you from absorbing B12 If you fit into one of these categories and notice symptoms, its worth getting your levels checked
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Insufficient autophagy inhibits Nrf2-mediated antioxidant defenses, promoting iron deposition and LPO, leading to ferroptosis (Peng et al., 2022)
Zuleika A