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Ultimately, it remains to be seen whether FDA can develop a clear OTC pathway for ENDS, and what types of companies would be able to take advantage of it

Furthermore, there is likely to be heterogeneity between social groups with varying background (and among never smokers) mortality rates due to differential timing of epidemiological transitions

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Evidence suggests that smoking may cause some mental health problems and that the tobacco withdrawal cycle partly contributes to worse mental health

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Cigarette smokers also have a greater likelihood of this happening, because their pastime already compromised their lungs