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Targeting RA ferroptosis as a potential therapeutic strategy ( 2.1 Iron metabolism in RA Iron plays an important role in human growth and development, immune system function, and energy metabolism ( 2+ and Fe 3+

In neutrophils and macrophages, NOX plays a crucial role in the oxidative burst, which involves the production of ROS for pathogen elimination [63]

Rushing through dose increases dramatically raises the risk of severe diarrhea and discontinuation

PPAR: Peroxisome Proliferator-Activated Receptor-

For neurological disorders, GPx safeguards neurons from oxidative insults, and reduced activity is linked to progression in conditions like Alzheimers or Parkinsons, where brain oxidation accelerates protein aggregation

Many early treatments were discovered serendipitously rather than through targeted drug development