The PCOS model was established through daily subcutaneous injections of dehydroisoandrosterone (DHEA, 60 mg/kg, LKT Laboratories) over a period of 20 days [20]
Researchers found that HR488B (HDACi) induces cell cycle G0/G1 arrest and apoptosis through mitochondrial dysfunction, reactive oxygen species (ROS) generation, and accumulation of DNA damage, thereby specifically inhibiting the growth of CRC cells
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Taken together, anti-apoptotic effects of PKC are associated with its ability to regulate the expression of anti-apoptotic and pro-apoptotic factors, a mechanism that cannot be achieved in mature erythrocytes
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