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doi: 10.1016/j.drup.2021.100744 52 TakamatsuSMurakamiKMatsumuraN

820,825,829 This suggests a conformational gating mechanism in HypB where GTP hydrolysis signals to the Ni II binding site through G3, thus initiating metal transfer to HypA, which itself later inserts Ni II into [NiFe]-hydrogenase (Figure 37, top )

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Sermorelin has the longest history of clinical use among this group