167 , 168 In addition, Xias group 169 administered a Xinjiang silkworm AMP named cecropin-XJ in combination with the chemotherapy drugs such as adriamycin (ADM), cisplatin (DDP), cyclophosphamide (CTX), and carboplatin (CBP) on esophageal cancer Eca109 cells, and results showed that the cell proliferation inhibition rate and the apoptosis rate of the combined drug group were significantly higher than those of the same concentration chemotherapeutic drug group
The stock solution was added to the 100 mL algalfungal co-cultures grown in 250 mL flasks to give final concentrations of co-trimoxazole of 1, 5, 10 and 20 ppm, respectively
Astone et al
Kakou, A
Systematic Review of Intravenous Ascorbate in Cancer Clinical Trials Source: PMC / BioMed Central Summary: A systematic review of Phase I/II trials evaluating intravenous vitamin C (ascorbate) in cancer settings, noting safety, tolerability, and potential clinical efficacy (often as an adjunct to chemotherapy)
What they found: Oral AOD-9604 reduced body fat by 18 to 22 % vs placebo, comparable to injection administration No changes in total body weight (because lean mass rose slightly) Decrease in plasma triglycerides by 30 % Decrease in resting free fatty acids (paradoxically, mobilization of fat from depots into oxidation) No GI side effects Why it matters: It suggested that AOD-9604 could work orally , a rare property for a peptide
