Felicia Morris Institution: Stanford Neuroscience Institute, USA Result: NSC transplantation in murine models of insomnia regenerated inhibitory neurons in the ventrolateral preoptic nucleus (VLPO), a sleep-promoting region
Stroke 49 , 27522760 (2018)
This anti-inflammatory peptide isnt a miracle cure
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The two cysteines in this motif catalyze glutathione (GSH)-dependent thiol-disulfide exchange reactions, i.e., the reduction of protein disulfides and, with high specificity, reversible (de-)glutathionylation [19] Oxidized Grxs are reduced by GSH, the resulting GSH disulfide (GSSG) by glutathione reductase (GR) using NADPH as electron source [20]
In addition to dedifferentiation, another consequence of in vitro expansion is replicative senescence, which also significantly influences chondrocyte function