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However, a landmark July 2025 study published in the Proceedings of the National Academy of Sciences (PNAS) by Shankar, Davis, Bonilla, et al., revealed a fascinating and complex paradox regarding redox homeostasis in these conditions

They have been widely used in gene editing owing to their high efficiency and accuracy

10.1146/annurev-biochem-060713-035314 87 ZeccaM.BaslerK.StruhlG