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By contrast, there is little evidence that modest intakes of folic acid, such as those typically found in multivitamin supplements, represent a significant concern for most people

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J Exp Med 209(6):12191234 Zanotelli MR, Reinhart-King CA (2018) Mechanical forces in tumor angiogenesis

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Based on the current evidence, we propose that the iron-overloaded, ROS-prone milieu of EMS renders EESCs susceptible to Erastin-triggered, multi-pathway regulated cell death that integrates ferroptosis with necroptotic and pyroptotic signaling, while ferritin handling and mitophagy act as key modulators of susceptibility