Health benefits and anti-inflammatory activities have been attributed to the activity of tocochromanol catabolites, especially the 13'-COOH catabolite since it inhibits 5-lipoxygenase a key enzyme in the biosynthesis of leukotrienes from arachidonic acid
GSH depletion by BSO treatment did not significantly increase caspase 3 activity (data not shown)
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Rats heal differently, metabolize compounds differently, and are studied under controlled conditions that dont reflect the complexity of human biology, health history, or dosing
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