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According to the National Institute of Diabetes and Digestive and Kidney Diseases, adults who are overweight or obese should lose 5% to 10% of their body weight within 6 months for weight loss success and better outcomes (12)

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Mutation of Tyr 180 to Ala reduced activity by ~80%, even though the side chain is far from the active site, so it is unlikely that Tyr 180 is involved in catalysis