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When mitochondrial function is impaired, enzyme complex IV in the inner mitochondrial membrane fails to produce water as it should, resulting in the production of O 2 -, which subsequently convert into OH and H 2 O 2

J Neurochem 120:147156 Tinggi U (2008) Selenium: Its role as antioxidant in human health

Glutathione may reduce melanin production, which could result in lightening of the skin

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S-acetyl L-glutathione , once inside the cells, can be readily converted to reduced glutathione, potentially offering a more efficient way to increase intracellular glutathione levels

Avoid layering GHK-Cu with strong actives like retinoids or AHAs in the same routine to reduce the risk of irritation