The authors declare that the research was supported by the United States of America National Institutes of Health National Institute on Aging (R01AG076704 to CN)
Preferential deimination of keratin K1 and filaggrin during the terminal differentiation of human epidermis
It performs a lot of functions in the body, such as Supports immune system Helps produce DNA, the building blocks of cells and proteins Breaks down free radicals Forms sperm cells Helps in the proper functioning of certain enzymes Regenerates vitamins C and E Helps gallbladder and liver dealing with fats Transports mercury off the brain Helps in apoptosis process (replacing dead cells) Low levels of glutathione are also linked with certain diseases
The monoamine theory of depression led to the development of both tricyclic antidepressants (TCAs) and serotonin-specific reuptake inhibitors (SSRIs), which both increase central monoamine levels
Monitoring mechanism-relevant endpoints: Track outcomes matching mechanisms targeted
7 Current challenges, future perspectives, and conclusions This review explores the complex relationship between sleep, redox metabolism, and aging, highlighting their critical role in brain health and longevity (Figure 1)
