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Viral entry is demonstrated to require the activity of the cysteine proteases cathepsin B and cathepsin L (CatB/L) as well as the serine protease TMPRSS2 for S protein priming

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doi: 10.1017/S0007114519003428 21

However, the absence of human clinical trials means the relevance and safety of these mechanisms in humans remains unestablished

CURRENT ANTI-OBESITY PHARMACOTHERAPY Anti-obesity pharmacotherapy is indicated as an adjunct to lifestyle interventions in adults with a BMI 30 kg/m 2 or a BMI 27 kg/m 2 in patients with additional weight-related comorbidities

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