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While generally less bothersome than nausea or vomiting, constipation can persist longer and may require proactive management through increased fiber intake, hydration, and physical activity

It is used to assist with the management of neuropathies

Both circulating and local IGF-1 levels are reduced in aging [189], with decreased Akt/mTOR/p70 S6K in skeletal muscle [9,189,190]

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Patients frequently report more profound, more restorative sleep as a welcome side effect of treatment

By enhancing autophagy, spermidine may support longevity, reduce inflammation, and contribute to healthier ageing across tissues