doi: 10.1111/gtc.13185 45 SarwarSRandallG
doi: 10.1016/j.eclinm.2021.101023 295 WongK
A role of oxidative stress in GO is supported by a number of basic studies suggesting that ROS promote the proliferation of OFs and the release of GAGs, the synthesis and secretion of cytokines, and the expression of other factors involved in the pathogenesis of GO, namely heat shock protein 72 (HSP-72), HLA-DR and ICAM-1 ( Figure 1 In this context, a number of studies, performed both in vitro and in vivo , investigated the effects of antioxidant agents in GO, including selenium, pentoxifylline, quercetin, enalapril, vitamin C, N-acetyl-L-cysteine and melatonin ( Oxidative Stress and Proliferation of Orbital Fibroblasts Burch et al
Promotes healthy cellular glutathione levels*
10.1186/s13098-020-0518-7 Diabetol
How to interpret folate tests: Folate can be directly tested with a serum folate test or a red blood cell (RBC) folate test