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This morphological state transition is critical for regulating BBB permeability and facilitating neurovascular coupling in response to local neural activity 22

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10.1212/wnl.62.11.2010 Neurology 154 RebuliM

Additionally, Ca 2+ overload induces K + efflux through Gardos channels [187] and promotes activation of cytoskeleton-degrading calpain [188], which consequently leads to the cell shrinkage and membrane blebbing, respectively

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