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Mechanistically, ALC exerts its antidepressant effects via multiple pathways, including enhancement of mitochondrial function, upregulation of brain-derived neurotrophic factor (BDNF), modulation of glutamatergic neurotransmission, and epigenetic regulation of gene expression involved in mood regulation

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Endurance athletes may be especially vulnerable because they may attempt to replace sweat losses by drinking large volumes of low electrolyte alkaline water instead of isotonic fluids formulated for proper rehydration (83)

doi: 10.2174/1871527314666150821103306 125 NguyenV

In contrast, testosterone is metabolized to estradiol by aromatase