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On the use of fluorescence lifetime imaging and dihydroethidium to detect superoxide in intact animals and ex vivo tissues: a reassessment

10.4266/acc.2018.00157 6

While hormonal changes and a diminishing ovarian reserve of oocytes, contribute to this decline, evidence indicates that the major driver of reduced fecundity in AMA is the progressive deterioration of oocyte quality, largely mediated by oxidative stress [11,12,13,14]

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(PubMed) Brooks JO, 3rd, Yesavage JA, Carta A, Bravi D