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GSH and Drug Detoxification: the Role of GSH S-Transferases Glutathione S-transferases (GSTs) are involved in drug detoxification through the conjugation of reactive drug metabolites to GSH [34, 58, 85]

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Whereas, GA (Group IV) pretreatment significantly prevented ISO-induced overexpression of TNF-, IL-6, NF-B, COX-2 and iNOS in rat cardiac tissue (Figure 5A,B)

Either the overproduction of the Fe 2+ that is involved in the formation of lipid hydroperoxides through the Fenton reaction 111 or the inactivation of glutathione peroxidase 4, which is programmed to degrade lipid hydroperoxides, leads to intracellular lipid hydroperoxide accumulation to a lethal level, ultimately triggering ferroptosis 112

After thoroughly washing with TBS-T, the membranes were developed by Pierce ECL western blotting substrate