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Keeping a headache diary and noting any patterns related to medication can help healthcare providers adjust treatment if needed

Ouellette AJ, Hsieh MM, Nosek MT, Cano-Gauci DF, Huttner KM, Buick RN, Selsted ME: Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms

Kidney protection evidence uses the 1.0 mg dose

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Instead of escalating every 4 weeks, increases happen every 6-8 weeks in smaller increments (1.0-1.5 mg instead of 2.5 mg)

10.3390/toxins9110348 267 SilvaJ.Monge-FuentesV.GomesF.LopesK.Dos AnjosL.CamposG.et al (2015)