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Mg 2+ ions are shown as magenta spheres

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As such, understanding how cagrilintide functionally engages target receptors is critical for future development of this target class

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Furthermore, a study revealed that liver-specific Zip8 KO mice exhibited significant decreases in systemic Mn levels under both Mn-rich and Mn-depleted conditions, indicating that hepatic ZIP8 mediates Mn reabsorption from bile to help maintain systemic homeostasis (Powers et al., 2023)