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For psoriasis, nasal delivery could be relevant for peptides that need systemic distribution but are poorly absorbed orally

Rybelsus (oral semaglutide): FDA-approved for type 2 diabetes, taken once daily on an empty stomach

Science 290 , 17171721 (2000)

Chronic hyperinsulinemia promotes human hepatocyte senescence

Using IV therapy to administer high doses of Vitamin C has been shown to reduce this toxicity, decreasing infections, bone marrow toxicity, liver and pancreatic toxicity, gastrointestinal toxicity, and dermatological toxicity